Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
AssigneeBristol-Myers Squibb Company
InventorsMaurizio Voi, David Lebwohl
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Abstract
Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative diseases.
Claims8
A method of treating cancer in a patient comprising administering to the patient the compound which is [1S1R*,3R*(E),7R*, 10S*, 11R*, 12R*, 16S*]]-7, 11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione (Compound 1), wherein Compound 1 is administered in a split dose, first on day 1 and then again on day 8, and carboplatin is administered on day 1, for at least one treatment cycle, wherein the cancer is selected from bladder cancer, pancreatic cancer, prostate cancer, lung cancer, colorectal cancer and breast cancer.
A method of treating cancer in a patient comprising administering to the patient the compound which is [1S1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione (Compound 1), wherein Compound 1 is administered in a split dose, first on day 1 and then again on day 8, and carboplatin is administered on day 1, for at least one treatment cycle, wherein the cancer is refractory to taxane treatment.
Dependencies are inferred from the claim text.