Pralmorelin-containing nasal drop preparations
AssigneeKaken Pharmaceutical Co., Ltd.
InventorsAkiko Ochiai, Yasutomi Kato, Hirokuni Kogetsu, Kiyoshi Maruyama
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Abstract
The preparation for intranasal administration comprising D-alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide (pralmorelin) and/or an acid addition salt thereof as an active ingredient and water permits a marked increase in the in vivo absorption of pralmorelin and hence provides adequate efficacy even if it is administered in a small dose at a time. The preparation also allows pralmorelin to be dissolved in an increased amount, so it can be formulated pharmaceutically with great ease. It also high stability over time.
Claims14
A preparation for intranasal administration which comprises D-alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide and/or an acid addition salt thereof as an active ingredient, and water, and has an osmolarity ratio of from not less than 0.01 to not more than about 0.5.
Dependencies are inferred from the claim text.