Glycopeptide phosphonate derivatives
AssigneeTheravance, Inc.
InventorsMichael R. Leadbetter, Martin S. Linsell
Life of this patent
Estimating the term…
Abstract
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
Claims18
A method of treating a staphylococcal infection in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically-acceptable salt thereof.
A method of treating a staphylococcal infection in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of the formula:
- or a pharmaceutically-acceptable salt thereof.
A method of treating a staphylococcal infection in a mammal where the infection is caused by methicillin-resistant Staphylococcus aureus, the method comprising administering a therapeutically effective amount of a composition comprising:
- (A) a compound of the formula:
- or a hydrochloride salt thereof;
- and
- (b) hydroxypropyl-β-cyclodextrin.
Dependencies are inferred from the claim text.