H-Y antigen
AssigneeRijksuniversiteit te Leiden
InventorsEls A. J. M. Goulmy, Donald F. Hunt, Victor H. Engelhard
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Abstract
The present invention relates to a peptide which is immunologically recognizable as a T cell epitope of the minor Histocompatibility antigen H-Y. The peptide comprises amino acid sequence SPSVDKARAEL (SEQ ID NO: 1) or FIDSYICQV (SEQ ID NO: 2). The peptide is obtainable from the minor Histocompatibility antigen H-Y. Providing a toxic moiety to the peptide eliminates T cells having specific binding affinity for the peptide. The peptide induces tolerance for transplantations when administered to H-Y-negative recipients.
Claims3
A method for inducing tolerance for transplants in a human that expresses HLA-B7 or a human that expresses HLA-A2.1, comprising administering to the human that expresses HLA-B7, and that is in need of tolerance for transplants, a tolerance-inducing amount of a peptide consisting of amino acid sequence SPSVDKARAEL (SEQ ID NO:1), or comprising administering to the human that expresses HLA-A2.1, and that is in need of tolerance for transplants, a tolerance-inducing amount of a peptide consisting of amino acid sequence FIDSYICQV (SEQ ID NO:2),
- whereby rejection of transplants or graft-versus-host reaction is reduced.
Dependencies are inferred from the claim text.