Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons
AssigneeArtemis Proteomics, Ltd.
InventorsGeorge Jackowski, Brad Thatcher, John Marshall, Jason Yantha, Tammy Vrees
Life of this patent
Estimating the term…
Abstract
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer.
Claims9
An isolated biopolymer marker consisting of SEQ ID NO:
- 1.
A method for determining the presence of a biopolymer marker having SEQ ID NO:
- 1 comprising:
- (a) obtaining a sample from a patient;
- (b) conducting mass spectrometric analysis on said sample in a manner effective to maximize elucidation of discernible peptide fragments contained therein, and comparing mass spectrum profiles of said biopolymer marker having SEQ ID NO:
- 1 to mass spectrum profiles of peptides elucidated from said sample;
- and
- (c) confirming the presence of said isolated biopolymer marker having SEQ ID NO:
- 1 in said sample displaying a peak profile at about 1077 Da in said mass spectrum profile.
A kit comprising:
- (a) an isolated biopolymer marker consisting of SEQ ID NO:
- 1 and (b) an antibody that binds to said isolated biopolymer in a sample from a patient.
Dependencies are inferred from the claim text.