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US 7,008,796 B2Granted
Assay sonication apparatus and methodology
AssigneeMesoScale Technologies, LLC.
InventorsJacob N. Wohlstadter, James Wilbur, George Sigal, Mark Martin, Alan Fischer, Larry R. Helms, Ramin Darvari
Life of this patent
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Abstract
An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
Claims13
A method for conducting an electrochemiluminescence assay to detect or quantitate an analyte comprising the steps of:
- (a) introducing a composition containing an analyte of interest bound to an electrochemiluminescent moiety into a cell including a working electrode;
- (b) sonicating said composition in said cell with means structurally coupled to said cell;
- (c) applying electrical energy to said electrode to cause said electrochemiluminescent moiety to luminesce;
- and
- (d) detecting or quantitating the electrochemiluminescence from said cell to detect or quantitate said analyte.
2 more elements
A method for conducting a binding assay comprising:
- (a) introducing a composition into a cell, comprising (i) a solid phase support, the solid phase support having a binding reagent immobilized thereon to form a binding domain and (ii) a sonication device structurally coupled to the cell, wherein said composition comprises at least one binding component that binds to said binding reagent;
- (b) sonicating the composition in the cell with the sonication device so as to increase the rate of binding reactions at the binding domain;
- and
- (c) detecting or quantitating the results of the binding assay.
1 more element
A method of conducting a solid phase binding assay wherein the solid phase is structurally coupled to a sonication device, the method comprising:
- (a) contacting the solid phase, said solid phase including a binding reagent, with a composition containing at least one binding component;
- and
- (b) sonicating the solid phase with the sonication device so as to increase the rate of binding reaction of said binding component to said solid phase.
Dependencies are inferred from the claim text.