Back to results
US 7,008,775 B2Granted
Diagnostic method for screening complement regulatory protein levels to predict spontaneous abortion
OwnerMark G. Martens, Anil K. Kaul +1inventors
InventorsMark G. Martens, Anil K. Kaul, Rashmi Kaul
Life of this patent
Estimating the term…
Abstract
The invention provides a method for the early detection of pregnancy failure, spontaneous abortion or premature birth by determinations of complement regulatory protein levels. A kit for use in rapid identification of these pregnancy complications is also provided.
Claims12
A method for diagnosing a predisposition for pregnancy failure or spontaneous abortion in a pregnant patient comprising:
- (a) measuring CD55 levels in a physiological fluid in a pregnant patient, wherein the CD55 levels are measured by measuring levels of complexes formed by contacting the physiological fluid with an anti-CD55 antibody;
- and
- b) determining whether CD55 levels in the physiological fluid of the patient are reduced relative to CD55 levels in a pregnant female patient not at risk of pregnancy failure or spontaneous abortion, wherein reduced CD55 levels are indicative for a predisposition for pregnancy failure or spontaneous abortion.
A method for diagnosing a predisposition for pregnancy failure, spontaneous abortion or premature birth in a pregnant patient comprising:
- (a) providing a sample obtained by contacting a physiological fluid from the patient, wherein the fluid potentially comprises a CRP from the patient, with a solid surface having immobilized thereon anti-CD55 antibodies, so that CRP present in the fluid binds to the anti-CD55 antibodies;
- (b) contacting the sample with labelled CD55, which comprises a detectable label or a binding site for a detectable label, so that the labeled CD55 binds to free antibodies on the solid surface to form detectable complexes;
- and
- (c) detecting the complexes, wherein the quantity of the complexes is inversely proportional to the amount of CD55 in the physiological fluid, and wherein a reduced quantity of CD55-antibody complexes in the patient relative to a corresponding control is indicative for a predisposition for pregnancy failure, spontaneous abortion or premature birth.
1 more element
Dependencies are inferred from the claim text.