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US 7,008,772 B1Granted
Compounds for immunodiagnosis of prostate cancer and methods for their use
AssigneeCorixa Corporation
InventorsJiangchun Xu, Davin C. Dillon
Life of this patent
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Abstract
Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
Claims3
A method for detecting prostate cancer in a patient, comprising:
- (a) contacting a biological sample selected from the group consisting of blood and sera obtained from the patient with a polyclonal or monoclonal antibody that is specific for the polypeptide sequence consisting of the amino acid sequence encoded by nucleotide residues 1341–2105 of SEQ ID NO:110;
- (b) detecting the level of the polypeptide encoded by SEQ ID NO:
- 110 in the sample bound by said antibody, and
- (c) comparing the level of the polypeptide detected in (b) with a predetermined cut-off value;
- thereby detecting prostate cancer in the patient, wherein an amount of polypeptide detected in (b) which is higher than that of the predetermined cut-off value is considered positive for prostate cancer.
2 more elements
Dependencies are inferred from the claim text.