Loading patent…
AssigneesThe Johns Hopkins University, Stichting Katholieke Universiteit more particularly The University Medical Centre
InventorsMarion J. G. Bussemakers, William B. Isaacs
Estimating the term…
The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1, 3, 4 or 6.
An isolated nucleic acid molecule consisting of 10 to 50 nucleotides which specifically hybridizes to PCA3 RNA or DNA, wherein said nucleic acid molecule is, or is complementary to, a nucleotide sequence consisting of at least 10 consecutive nucleotides from PCA3 exon 1 (1–98 of SEQ ID NO:1 or 1–120 of SEQ ID NO:6), 2 (99–263 of SEQ ID NO:1 or 121–285 of SEQ ID NO:6), 3 (264–446 of SEQ ID NO:1 or 286–468 of SEQ ID NO:6), 4a (447–985 of SEQ ID NO:1 or 469–1007 of SEQ ID NO:6), 4b (986–2037 of SEQ ID NO:1 or 1008–2066 of SEQ ID NO:6), 4c (2067–2622 of SEQ ID NO:6), or 4d (2623–3582 of SEQ ID NO:6), and wherein said nucleic acid molecule does not specifically hybridize to nucleotides 511–985 of SEQ ID NO:1 or nucleotides 533–1007 of SEQ ID NO:6.
An isolated nucleic acid molecule comprising the polynucleotide sequence set forth from nucleotides 401 to 553 of SEQ ID NO:6.
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
An isolated nucleic acid molecule consisting of 10 to 50 nucleotides which specifically hybridizes to PCA3 RNA or DNA, wherein said nucleic acid molecule is, or is complementary to, a nucleotide sequence consisting of at least 10 consecutive nucleotides from PCA3 exon 1 (1–98 of SEQ ID NO:1 or 1–120 of SEQ ID NO:6), 2 (99–263 of SEQ ID NO:1 or 121–285 of SEQ ID NO:6), 3 (264–446 of SEQ ID NO:1 or 286–468 of SEQ ID NO:6), 4a (447–985 of SEQ ID NO:
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
Dependencies are inferred from the claim text.