Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue

Collagenous connective tissue specimen having a structure of collagen fibers from an animal donor source such that upon implant of said tissue into a recipient said tissue contains an anti-inflammatory agent and is acceptable to the recipient without an immune rejection where said tissue is prepared in a method having the steps of:

• (a) stabilizing the collagen fibers contained in said collagenous connective tissue in a cold stabilizing solution at a temperature sufficient to retain the structure of the collagen fibers where said temperature range is 4 to 10 degrees centigrade;
• (b) soaking said collagenous connective tissue in a first solution comprising predetermined quantitities and concentrations of polyglycol, an oxidizing agent, salt and phosphate buffer at a predetermined temperature where said first solution is of sufficient ionic strength to permit ground substances to dissociate from said collagenous connective tissue such that the collagen fibers remain stable;
• (c) after step (b), washing said collagenous connective tissue in predetermined quantitities and concentrations of a second solution comprising alcohol and water for a sufficient period of time at a predetermined temperature to sufficiently remove the residue of said first solution therefrom;
• and
• (d) soaking said collagenous connective tissue in a third solution comprising a predetermined quantity and concentration of an anti-inflammatory agent at a predetermined temperature.