Compositions for achieving a therapeutic effect in an anatomical structure and methods of using the same
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsWouter E. Roorda, Stephen D. Pacetti
Life of this patent
Estimating the term…
Abstract
Compositions and methods of using the compositions to achieve a therapeutic effect are provided.
Claims35
A method of achieving a therapeutic effect comprising:
- delivering a particle containing a therapeutic substance and a disintegrant to an anatomical structure comprising a lumen such that said particle forms an embolus within said lumen for a transitory period, said transitory period being less than seven days and less than the duration which results in cell damage or cell death;
- and
- wherein said therapeutic substance is released from said particle, causing said therapeutic effect.
A method of achieving a therapeutic effect comprising delivering a particle comprised of a disintegrant and a therapeutic substance to an anatomical structure including a lumen, said particle having a first diameter sufficient to form an embolus within said lumen at a first site;
- wherein said disintegrant is capable of causing said particle to degrade within said lumen to a second diameter smaller than the diameter of said lumen at said first site in less than seven days to release said particle from said first site to mitigate or prevent cellular damage at said first site.
A method of achieving a therapeutic effect within an anatomical structure having a first region and a second region, said second region being located downstream of said first region and having a smaller cross-sectional diameter than said first region, the method comprising:
- delivering a particle having a first size in which said particle is dot capable of passing from said first region into said second region, said particle comprising a water soluble polymer and a hydrophobic counterion;
- and
- wherein said particle subsequently reduces from said first size to a smaller second size as said particle travels through said anatomical structure;
- allowing said particle to pass into said second region.
A method of releasing a therapeutic substance in a lumen comprising delivering a particle comprised of a biodegradable compressed material and a therapeutic substance to a lumen, said particle having a first diameter sufficient to form an embolus within said lumen at a first site.
A method of delivering a therapeutic substance to a lumen network, said lumen network having a plurality of branched lumens, said method comprising:
- occluding a portion of said lumen network;
- and
- delivering a particle to a lumen in said lumen network upstream of said occlusion, the particle comprising a biodegradable substance, wherein said occlusion prevents said particle from entering said portion of said lumen network.
A method of delivering a biodegradable substance to a lumen network, the lumen network having a first region and a second region branching from said first region downstream from said first region, wherein said second region has a first branch and a second branch, said method comprising:
- occluding said first branch of said second region;
- and
- delivering a particle to said first region upstream of said occlusion, the particle comprising a biodegradable substance and having a first diameter sufficient to form an embolus within said second branch of said second region.
A method of treatment, comprising delivering a particle to a lumen, said particle comprised of a substance and a disintegrant, said disintegrant allowing said particle to form multiple emboli at different periods of time within said lumen.
A method of releasing a therapeutic substance in a lumen comprising delivering a particle comprised of a biodegradable inorganic substance and a therapeutic substance to a lumen, said biodegradable inorganic substance allowing said particle to form multiple emboli at different periods of time within said lumen.
A method of releasing a therapeutic substance in a lumen comprising delivering a particle comprised of surfactant and a therapeutic substance to a lumen, said particle having a first diameter sufficient to form an embolus with said lumen at a first site.
Dependencies are inferred from the claim text.