US 7,008,640 B2 · Pharmaceutical composition for oral use with improved absorption

Abstract

The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

Claims21

Dependent claims

A method for improving the absorption of a drug from the digestive tract, said method comprising:

orally administering a pharmaceutical composition obtained by bringing said drug, aminoalkyl methacrylate copolymer E, and an acidic substance together through the uniform mixing of at least the polymer and the acidic substance, wherein the acidic substance is present in an amount that neutralizes 10% or more of the basic groups of the polymer and increases the absorption of said drug from the digestive tract, wherein said drug is a bisphosphonate compound.

Dependencies are inferred from the claim text.

Facts

Application

09/907,557Filed 16 Jul 2001 · us provisional application

Priority

17 Jul 2000

Published

US 2002/0150624 A117 Oct 2002

Granted

7 Mar 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification47 codes

A61K 9/2027
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/2846
Obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone: polyacrylates
A61K 9/2853
Organic macromolecular compounds: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene…
A61K 9/2893
Dragees; Coated pills or tablets , e.g. with film or compression coating: tablet coating processes

Pharmaceutical composition for oral use with improved absorption

Life of this patent

Pharmaceutical composition for oral use with improved absorption

Life of this patent

Abstract

Claims21