Local regional chemotherapy and radiotherapy using in situ hydrogel
AssigneeBoard of Regents, The University of Texas System
InventorsDavid J. Yang, Dong-Fang Yu, Ali Azhdarinia, Tommy L. Lee, E. Edmund Kim
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Abstract
Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polyamino acid, with a therapeutic agent, such as a radionuclide or a drug, and administering a cross-linking agent. The hydrogel/therapeutic agent composition is retained in the tumor for safe and efficient tumor therapy. Alternatively, a hydrogel composition is generated in situ in an artery which nourishes a tumor to occlude the artery.
Claims61
A method of dispensing a therapeutic agent in situ to a localized region in an individual comprising administering to said region a polymer composition that comprises a biocompatible polymer, a cross-linking composition that comprises a cross-linker, and the therapeutic agent, wherein the biocompatible polymer and the cross-linking composition are administered to allow formation of a cross-linked polymer in situ at the localized region, which cross-linked polymer comprises the therapeutic agent, and wherein the biocompatible polymer and the cross-linking composition are administered to the localized region from separate containers, wherein a first container comprises the biocompatible polymer and a second container comprises the cross-linking composition.
The method of claim of 13, wherein the therapeutic agent is a radionuclide, and the radionuclide is 188Re, 213Bi, 166Ho, 211At, or a combination thereof.
A method of treating a tumor in situ in an individual comprising the steps of administering to said tumor a polymer composition that comprises a biocompatible polymer, a cross-linking composition that comprises a cross-linker, and a therapeutic agent, wherein the biocompatible polymer and the cross-linking composition are administered to allow formation of a cross-linked polymer in situ at the tumor, which cross linked polymer comprises the therapeutic agent, and wherein the biocompatible polymer and the cross-linking composition are administered to the tumor from separate containers, wherein a first container comprises the biocompatible polymer and a second container
A method of occluding an artery associated with a tumor in an individual comprising the step of administering to said tumor a polymer composition that comprises a biocompatible polymer and a cross-linking composition that comprises a cross-linker, wherein the biocompatible polymer and the cross-linking composition are administered to allow formation of the cross-linked polymer in situ at the tumor, wherein the biocompatible polymer and the cross-linking composition are administered to the tumor from separate containers, wherein a first container comprises the biocompatible polymer and a second container comprises the cross-linking composition.
A method of dispensing a therapeutic agent in situ to a localized region in an individual comprising administering to said region a polymer composition that comprises a biocompatible polymer, a cross-linking composition that comprises a cross-linker, and the therapeutic agent, wherein the polymer composition and the cross-linking composition are administered to allow formation of a cross-linked polymer in situ at the localized region, which cross-linked polymer comprises the therapeutic agent, wherein the polymer composition and the cross-linking composition are separately administered to the localized region by means of a single container having at least two compartments, wherein one compartment comprises the polymer composition and another compartment comprises the cross-linking composition.
A method of dispensing a therapeutic agent in situ to a localized region in an individual comprising administering to said region a polymer composition that comprises a biocompatible polymer, a cross-linking composition that comprises a cross-linker, and the therapeutic agent, wherein the polymer composition and the cross-linking composition are administered to allow formation of a cross-linked polymer in situ at the localized region, which cross-linked polymer comprises the therapeutic agent, wherein the polymer composition and the cross-linking composition are separately administered to the localized region by means of a single container having a hollow cylindrical compartment, wherein the polymer composition and cross-linking composition are administered separately through said compartment.
Dependencies are inferred from the claim text.