End modified thermal responsive hydrogels
AssigneeMadasa LLC
InventorsEyal S. Ron, Lev Bromberg, Marina Temchenko
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Abstract
A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosifies in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.
Claims29
A reverse thermally viscosifying composition comprising:
- a block copolymer in an aqueous medium, the block copolymer comprising,
- a first polyoxyalkylene block having a hydrophobic region and a hydrophilic region, said polyoxyalkylene block forming micelles in solution in response to a change in temperature, and
- at least a second block comprising a bioadhesive polymer or oligomer,
- wherein the composition reversibly viscosifies at a temperature in the range of about 22° C. to about 40° C.
A pharmaceutical composition, comprising:
- a reverse thermally viscosifying composition comprising,
- a block copolymer having first and second blocks in an aqueous medium, wherein the first block comprises a polyoxyalkylene having a hydrophobic region and a hydrophilic region;
- said polyoxyalkylene block forming micelles in solution in response to a change in temperature, and the second block comprises a bioadhesive polymer or oligomer;
- and
- an active agent which imparts a pharmaceutic or cosmetic effect, said composition characterized in that it viscosifies at a temperature in the range of about 22° C. to about 40° C.
Dependencies are inferred from the claim text.