Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome
AssigneeFuji Photo Film Co., Ltd.
InventorsHiroshi Kitaguchi, Kazuhiro Aikawa
Life of this patent
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Abstract
A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component: R1—CO2—R2 wherein R1 represents a substituted or unsubstituted 2,3,5-triiodophenyl group or a substituted or unsubstituted 3,4,5-triiodophenyl group; and R2 represents a hydrocarbon group having 10 or more carbon atoms, and an X-ray contrast medium, which comprises said liposome which is used for radiography of a vascular disease.
Claims11
A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component:
- R1—CO2—R2
- wherein R1 represents a substituted or unsubstituted 2,3,5-triiodophenyl group or a substituted or unsubstituted 3,4,5-triiodophenyl group;
- and R2 represents a hydrocarbon group having 10 or more carbon atoms, wherein said hydrocarbon group is a residue of a cholesterol derivative.
An X-ray contrast medium for radiography of a tissue or a lesion in which macrophages localize, which comprises a liposome containing a hydrophobic iodine compound, phosphatidylcholine, and phosphatidylserine as membrane components, wherein said hydrophobic iodine compound has as a substituent a hydrocarbon group having 10 or more carbon atoms and which is a residue of a cholesterol derivative.
Dependencies are inferred from the claim text.