Method and apparatus for reproducible dissolution testing of pharmaceutical products
AssigneeHer Majesty the Queen in right of Canada, as represented by the Minister of Health
InventorSaeed A. Qureshi
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Abstract
In a method for reproducible dissolution of a pharmaceutical product in a dissolution medium contained within a vessel, a flow regime characterized by high turbidity and low bulk movement of dissolution medium is induced within the vessel. Simultaneously, solid particles of the pharmaceutical product on a bottom portion of the vessel are mechanically dispersed. Induction of the flow regime and mechanical dispersion of solid particles may be accomplished by a brush body adapted to sweep a bottom portion of the vessel. The brush body is repeatably biased into contact with the bottom portion of the vessel, and caused to rotate in a controlled manner.
Claims9
A method for controlled dissolution of a pharmaceutical product in a dissolution medium contained within a vessel, the method comprising steps of:
- inducing a flow regime within the vessel characterized by high turbidity and minimum bulk movement of the dissolution medium;
- and
- simultaneously mechanically dispersing solid particles of the pharmaceutical product on a bottom portion of the vessel;
- wherein the steps of inducing a flow regime within the vessel and simultaneously dispersing solid particles comprise steps of:
- providing a brush body adapted to sweep a bottom portion of the vessel;
- repeatably biasing the brush body into sliding engagement with the bottom portion of the vessel and;
- causing controlled rotation of the brush body within the vessel.
Dependencies are inferred from the claim text.