Low temperature adaptor for evaporative light detection

Detecting consecutive samples by evaporative light scattering detection according to the split-flow method and the single-flow method of evaporative scattering light detection comprising the steps of:

• (a) providing an evaporative light scattering device comprising a nebulizer;
• a drift tube channel downstream in the direction of sample flow and in flow communication with the nebulizer, a photodetector downstream in the direction of sample flow from the nebulizer;
• and a light source downstream in the direction of sample flow from the nebulizer;
• (b) flowing a first sample comprising previously separated components to be detected and mobile phase through the evaporative light scattering device and detecting the separated components of the, first sample by one of the evaporative light scattering detection methods selected from the group consisting of the split-flow method and the single-flow method;
• (c) after step (b), flowing a second sample comprising previously separated components to be detected, and mobile phase through the evaporative light scattering device and detecting the separated components of the, second sample by the evaporative light scattering detection method selected from the group consisting of the split-flow method and the single-flow method wherein the method selected in step (c) is different than the method selected in step (b).