US 7,002,688 B2Granted

Multilens optical assembly for a diagnostic device

AssigneePria Diagnostics, Inc.

InventorsAlexander M. Aravanis, Raymond T. Hebert, Bryan E. Loucks, John D. Lytle, Jason L. Pyle

Life of this patent

Estimating the term…

Loading patent…

Abstract

A diagnostics apparatus for detecting fluorescence events related to the presence of an analyte in a sample is disclosed. The apparatus includes a housing, a source of excitation light and a photodetector, and a unitary multi-surface optical module. The optical module is integrally formed and composed of an upstream portion having a focusing optical surface for directing excitation light from the light source to a focal region within an analyte-detection zone in the apparatus, and a downstream portion having a second focusing powered optical surface and at least one reflecting surface for directing fluorescence-emission light produced by fluorescence events within the detection zone, in a direction substantially normal to the path of the excitation light onto the photodetector. The optical module is adaptable to a variety of assay formats, including multiple-sample, sample-array, and disposable-cartridge formats.

Claims25

Dependent claims

A diagnostics apparatus for detecting fluorescence events related to the presence of an analyte in a sample applied to the apparatus, comprising

(a) a housing,
(b) a source of excitation light and a photodetector mounted in said housing,
(c) a multi-surface optical module carried in said housing, adjacent said light source and photodetector, and comprising:
(ci) an upstream portion having a first focusing surface for directing excitation light from said light source to a focal region within an analyte-detection zone in said apparatus, and
(cii) a downstream portion having a second focusing surface and at least one reflecting surface for directing fluorescence-emission light produced by fluorescence events within said detection zone, in a direction substantially normal to the path of said excitation light within the detection zone, onto said photodetector,
(d) a display carried on said housing, and
(e) a microprocessor in said housing operatively coupled to:
(ei) said excitation light source for activating the same,
(eii) said photodetector for receiving electronic signals therefrom, and for converting said signals to an analyte-detection signal, and
(eiii) to said display for displaying said detection signal.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/865,100Filed 9 Jun 2004 · continuation in part
Priority: 16 Oct 2003
Published: US 2005/0083522 A121 Apr 2005
Granted: 21 Feb 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

G01N 21/645
Fluorescence; Phosphorescence: specially adapted constructive features of fluorimeters
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
G01N 15/1459
Without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals: the analysis being performed on a…
G01N 15/1484
Optical investigation techniques, e.g. flow cytometry: microstructural devices

Family

Application60/511,798Us provisional application · filed 16 Oct 2003
Application10/705,162Parent of this continuation-in-part · filed 6 Nov 2003
US 2005/0083522 A1Pre-grant publication · published 21 Apr 2005
US 6,929,945 B2Parent of this continuation-in-part
US 2004/0146850 A1Published application
US 7,002,688 B2This patent

From the US filing history. Foreign family members aren’t listed.