Compositions and methods for therapeutic use
AssigneesCanji, Inc., Schering Corporation
InventorsHeidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
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Abstract
The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeutic or diagnostic agents, such as proteins, nucleic acids, antisense RNA, small molecules, etc., for administration to any tissue or organ having an epithelial membrane. The delivery-enhancing agents include detergents, alcohols, surfactants and other molecules.
Claims3
A compound of Formula I:
- wherein:
- n is 3;
- X1 and X2 are both cholic acid groups;
- wherein the cholic acid group has the formula:
- and X3 is a pentose monosaccharide group.
A compound having the formula:
- 3′-N-gluconamidopropyl-3″-N-cholamidopropyl-N-cholamide.
A compound of Formula I:
- wherein:
- n is 3;
- X1 and X2 are both cholic acid groups;
- wherein the cholic acid group has the formula:
- and X3 is a hexose monosaccharide group.
Dependencies are inferred from the claim text.