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US 7,001,984 B2Granted
Di-, tri-, and tetra-peptides having antiangiogenic activity
AssigneeAbbott Laboratories
InventorsFortuna Haviv, Michael F. Bradley
Life of this patent
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Abstract
Compounds having the formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
Claims16
The compound of formula (I)
- Xaa1-Xaa2-Xaa3-Xaa4-Xaa5(SEQ ID NO:1) (I),
- or therapeutically acceptable salt thereof, wherein
- Xaa1 is R—(CH2)n—C(O)—;
- n is 0;
- R is selected from the group consisting of alkyl and heterocycle, wherein the alkyl is selected from the group consisting of methyl and n-butyl, and wherein the heterocycle is 6-methylpyridinyl;
- Xaa2 is selected from the group consisting of D-alanyl, arginyl, asparaginyl, aspartyl, citrullyl, glutaminyl, histidyl, isoleucyl, D-isoleucyl, D-leucyl, D-lysyl(N-epsilon acetyl) lysyl(N-epsilon acetyl), lysyl(N-epsilon-nicotinyl), methionyl, norleucyl, ornithyl, prolyl, homoseryl, seryl, allothreonyl, and threonyl;
- Xaa3 is selected from the group consisting of arginyl and citrullyl;
- Xaa4 is absent or prolyl;
- and
- Xaa5 is selected from the group consisting of D-alanylamide, —NHCH2CH3, and —NHCH(CH3)2.
7 more elements
Dependencies are inferred from the claim text.