Formate salt of O-desmethyl-venlafaxine
AssigneeWyeth
InventorsAnthony Francis Hadfield, Michael William Winkley
Life of this patent
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Abstract
A novel salt of O-desmethylvenlafaxine, O-desmethylvenlafaxine formate, is provided. Pharmaceutical compositions, dosage forms and methods of use are also provided.
Claims47
A compound which is crystalline O-desmethylvenlafaxine formate.
A pharmaceutical composition comprising O-desmethylvenlafaxine formate and a pharmaceutically acceptable carrier or excipient.
A pharmaceutical dosage form comprising a therapeutically effective amount of O-desmethylvenlafaxine formate and a pharmaceutically acceptable carrier or excipient.
A method of treating a patient suffering from depression comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from anxiety comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from panic disorder comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from generalized anxiety disorder comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from post traumatic stress disorder comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from premenstrual dysphoric disorder comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from a condition selected from fibromyalgia, agorophobia, obsessive compulsive disorder, attention deficit disorder, social anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, chronic fatigue syndrome, incontinence, pain, Raynaud's syndrome, Parkinson's disease, and epilepsy comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of enhancing cognition in a patient comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method of treating a patient suffering from a pain disorder comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate.
A method for promoting smoking cessation or reduction or preventing relapse smoking in a patient, which method comprises administering an effective amount of O-desmethylvenlafaxine formate to the patient.
A method of treating a patient suffering from a condition selected from the group consisting of depression, fibromyalgia, anxiety, panic disorder, agoraphobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, chronic fatigue syndrome, incontinence, pain, Raynaud's syndrome, Parkinson's Disease and epilepsy comprising providing to the patient an effective amount of O-desmethylvenlafaxine formate salt in combination with an effective amount of venlafaxine.
A method of preparing O-desmethylvenlafaxine formate comprising reacting O-desmethylvenlafaxine and formic acid in ethanol.
A method of preparing O-desmethylvenlafaxine formate comprising reacting formic acid and O-desmethylvenlafaxine in tetrahydrofuran.
A method of preparing O-desmethylvenlafaxine formate comprising reacting O-desmethylvenlafaxine and formic acid in acetone.
A method of preparing O-desmethylvenlafaxine formate comprising reacting O-desmethylvenlafaxine and formic acid in 2-propanol.
Dependencies are inferred from the claim text.