Pyrazole compounds as anti-inflammatory and analgesic agents
AssigneeWarner-Lambert Company
InventorsMisato Hirano, Kazunari Nakao, Seiji Nukui, Tatsuya Yamagishi
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Abstract
This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryl1, etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglandin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.
Claims13
A compound of the following formula (I):
- wherein:
- R1 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an amino group, mono- or di-alkylamino groups, the alkyl group(s) having from 1 to 6 carbon atoms, or an aryl group;
- R2 represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a cycloalkenyl group having from 3 to 10 carbon atoms, an aralkyl group, or an aryl group;
- R3 represents an alkyl group having from 1 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, a hydroxyalkyl group having from 1 to 6 carbon atoms, or an aryl group;
- R4 represents an aryl group;
- A represents an aryl group having from 6 to 10 carbon atoms;
- B represents an alkylene group having from 1 to 6 carbon atoms;
- X represents NH, N[(C1-C6)alkyl], oxygen or sulfur;
- said aryl groups have 6 to 14 carbon atoms;
- said aryl groups are unsubstituted or are substituted by at least one substituent selected from the group consisting of substituents α, defined below;
- said aralkyl groups are alkyl groups having from 1 to 6 carbon atoms and which are substituted by at least one aryl group as defined above;
- said substituents α are selected from the group consisting of an aryl group as defined above, hydroxy group, halogen atoms, alkyl group having from 1 to 6 carbon atoms, alkoxy group having from 1 to 6 carbon atoms, alkylthio group having from 1 to 6 carbon atoms, alkanoyl group having from 1 to 6 carbon atoms, alkanoylamino group having from 1 to 6 carbon atoms, alkanoylaminoalkyl group having from 1 to 6 carbon atoms in the alkanoyl and alkyl part, amino group, mono- or di-alkylamino group having from 1 to 6 carbon atoms, haloalkyl group having from 1 to 6 carbon atoms, haloalkoxy group having from 1 to 6 carbon atoms, carbamoyl group, cyano group, a hydroxyalkyl group having from 1 to 6 carbon atoms, alkylsufinyl group having from 1 to 6 carbon atoms, alkylsufonyl group having from 1 to 6 carbon atoms, aminoalkoxy group having from 1 to 6 carbon atoms, mono- or di-alkylaminoalkoxy group, the alkyl group(s) having from 1 to 6 carbon atoms in the alkyl and alkoxy part, alkylsulfonylamino group having from 1 to 6 carbon atoms and aminosulfonyl group;
- with the proviso that said aryl group in said substituents α are not substituted by an aryl group;
- or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.