Thiazolidinedione derivatives as antidiabetic agents
AssigneeVita-Invest, S.A.
InventorsMarisabel Mourelle Mancini, Juan Carlos Del Castillo Nieto, Elisabet De Ramon Amat
Life of this patent
Estimating the term…
Abstract
The present invention refers to compounds of the general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The present invention also refers to a process for their production and to their use as antidiabetic and *hypoglycemic agents, alone or in combination with other antidiabetic agents, such as sulfonilureas or biguanides, as well as for the treatment of complications associated to the resistance to the insulin, such as hypertension, hyperuricemia or other cardiovascular, metabolic, endocrine conditions, or other conditions related with diabetes.
Claims11
A compound of the general formula
- wherein:
- R1 is:
- H or C1–C6 alkyl,
- R2:
- H, C1–C6 alkyl, halogen (F, Cl, Br, I), OR5, SR5, NR5R6, NO2, or phenyl,
- R3:
- H, C1–C6 alkyl, halogen (F, Cl, Br, I), OR5, SR5, NR5R6, NO2, or phenyl,
- R4:
- H, C1–C6 alkyl, halogen (F, Cl, Br, I), OR5, NR5R6, phenyl,
- or R3 and R4, when taken together, are —CH═CH—CH═CH—
- forming a fused ring on the pyrimidine ring
- R5, R6:
- independently to each other, may be H or C1–C6 alkyl,
- R7:
- H or NH2,
- R8:
- H, C1–C6 alkyl,
- or a pharmaceutically acceptable salt or tautomeric form thereof.
Dependencies are inferred from the claim text.