Substituted heterocyclic compounds

A compound of the formula:

• wherein:
• R1, R2, R3, R4, R5, R6, R7, and R8 are hydrogen, lower alkyl, or —C(O)R;
• in which R is —OR9 or NR9R10, where R9 and R10 are hydrogen or lower alkyl;
• or
• R1 and R2, R3 and R4, R5 and R6, R7 and R8, when taken together with the carbon to which they are attached, represent carbonyl;
• or
• R1 and R5, or R1 and R7, or R3 and R5, or R3 and R7, when taken together form a bridging group —(CR12R13)n—, in which n is 1, 2 or 3, and R12 and R13 are independently hydrogen or lower alkyl;
• with the proviso that
• (a) the maximum number of carbonyl groups is 2;
• (b) the maximum number of —C(O)NR9R10 groups is 1;
• and
• (c) the maximum number of bridging groups is 1;
• T is oxygen, or NR11, in which R11 is hydrogen or lower alkyl;
• V is —N<,
• X1 is optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• X2 is optionally substituted aryl or optionally substituted heteroaryl;
• Y is optionally substituted monocyclic heteroarylenyl;
• and
• Z1 and Z2 are independently optionally substituted alkylene of 1–4 carbon atoms.