Peptide-containing α-ketoamide cysteine and serine protease inhibitors

A compound having the Formula I:

• wherein:
• Q is (lower alkyl)-S(O)2— or arylalkyl-OC(═O)—, said arylalkyl having from 7 to 15 carbons;
• Aaa is an amino acid;
• n is 0 or 1;
• M is a carbon atom;
• R1 is selected from the group consisting of alkyl having from one to 6 carbons and alkoxyalkyl, said alkyl and alkoxyalkyl groups being optionally substituted with phenyl;
• R2 is benzyl;
• R3 is H;
• q is 1;
• Z is —C(═O)C(═O)NH-X-A1-K;
• X is a bond;
• A1 is —CH2—CH2—, —CH2—CH(CH3)—, or —CH(CH3)—CH2—;
• K is —NHSO2R8;
• R8 is aryl, said aryl being substituted with one J group;
• J is piperazinyl-CH2— optionally substituted by a J1 group;
• J1 is selected from the group consisting of halogen, CN, nitro, lower alkyl, cycloalkyl, heterocycloalkyl, heteroalkyl, halogenated alkyl, aryloxyalkyl, alkylthio, alkylsulfonyl, aryl, heteroaryl, arylalkyl, arylalkyloxy, arylsulfonyl, heteroarylsulfonyl, alkoxycarbonyl, alkoxyalkyl, acyl, alkoxy, hydroxy, carboxy, hydroxyalkyl, amino, alkylamino, and aminoalkyl, said amino group or said amino group of said aminoalkyl or alkylamino group being optionally substituted with an acyl group, an alkoxy group, or with 1 to 3 aryl, lower alkyl, cycloalkyl, or alkoxyalkyl groups;
• and said aryl, heteroaryl, heterocycloalkyl, and heteroalkyl groups being further optionally substituted by a J2 group;
• and
• J2 is selected from a group consisting of halogen, CN, nitro, lower alkyl, halogenated alkyl, alkylthio, alkylsulfonyl, alkoxycarbonyl, alkoxyalkyl, acyl, alkoxy, hydroxy, carboxy, hydroxyalkyl, amino, alkylamino, and aminoalkyl;
• or a pharmaceutically acceptable salt thereof.