Nonpeptide substituted spirobenzoazepines as vasopressin antagonists

A compound of Formula (I),

• wherein
• R1 is one to three substituents independently selected from hydrogen, halogen, amino, substituted amino, hydroxy, alkyloxy, phenyl, substituted phenyl, alkylthio, arylthio, alkyl-sulfoxide, aryl-sulfoxide, alkyl-sulfone, and aryl-sulfone;
• R4 is one or two substituents independently selected from the group consisting of hydrogen, alkyl, substituents alkyl, phenyl, and substituted phenyl;
• R5 is selected from hydrogen, alkyl, substituents alkyl, aldehyde, carboxyl, alkoxycarbonyl, substituted alkoxycarbonyl, —(CH2)kNZ1Z2 and —CONZ1Z2 wherein k is an integer from 1-4, and Z1 and Z2 are independently selected from hydrogen, alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, aminocarbonyl, and substituted aminocarbonyl, or N, Z1 and Z2 together form heterocyclyl, substituted heterocyclyl, heteroaryl, or substituted heteroaryl;
• a represents double bond;
• A is selected from phenyl;
• X is selected from CH;
• and
• n is 1, 2, or 3;
• or an optical isomer, enantiomer, diastereomer, racemate thereof, or a pharmaceutically acceptable salt thereof.