Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsKakulapati Rama Rao, Nanduri Bhanumathi, Jhillu Singh Yadav, Neelam Srilakshmi Krishnaveni
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Abstract
The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for synthesizing inclusion complexes of the anti-tubercular drug, Rifampicin, with β-CD (β-cyclodextrin) and HP-β-CD (2-hydroxy propyl cyclodextrin) and characterization of these inclusion complexes.
Claims14
An inclusion complex of Rifampicin and cyclodextrin with an X-ray diffraction profile where there are peaks at about 18.6, 25.5 and 46.4.
A process for preparing inclusion complexes of Rifampicin and β-cyclodextrin, said process comprising adding Rifampicin to cyclodextrin and grinding in an agate mortar to form a uniform powdery material of Rifampicin-cyclodextrin inclusion complex wherein the complex has enhanced bioavailability and solubility of the drug Rifampicin, and the inclusion complex provides improved stability of Rifampicin in fixed dose combination.
An inclusion complex of Rifampicin and 2-hydroxy propyl β-cyclodextrin with an X-ray diffraction profile where there are peaks at about 14.2 and 25.8.
Dependencies are inferred from the claim text.