Biodegradable polycation composition for delivery of an anionic macromolecule
AssigneeEfrat Biopolymers Ltd.
InventorAbraham J. Domb
Life of this patent
Estimating the term…
Abstract
The present invention provides a biodegradable polycation composition for delivery of an anionic macromolecule, comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000 and at least one grafted oligoamine per 5 saccharide units, wherein said oligoamine is selected from the group consisting of a linear, branched and cyclic alkyl amine having at least two amino groups.
Claims19
A biodegradable polycation composition associated with an anionic macromolecule, the macromolecule being selected from the group consisting of a plasmid, an oligonucleotide, an antisense, a peptide, a protein, an anionic polysaccharide and combinations thereof, comprising:
- a) a natural or synthetic linear polysaccharide chain having an amount of saccharide units ranging from 2 to 2000;
- and
- b) at least one grafted oligoamine per 5 saccharide units, wherein the oligoamine is selected from the group consisting of a linear, branched and cyclic alkyl amine having at least two amino groups and the oligoamine has a molecular weight of up to 1000 Daltons.
Dependencies are inferred from the claim text.