Compositions and methods for treating cancer
AssigneeThreshold Pharmaceuticals, Inc.
InventorsGeorge Tidmarsh, Mark Matteucci, Photon Rao
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Abstract
Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells.
Claims8
A method for treating a cancer selected from the group consisting of lung cancer, breast cancer, colon cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, skin cancer and melanoma and low and intermediate grade non-Hodgkin's Lymphoma in a subject, said method comprising administering to said subject an effective amount of a glucose-anti-neoplastic agent conjugate having the formula:
- wherein L is selected from the group consisting of a bond, alkenyl, alkylamine, alkylether, amide, carbamate, urea, thiocarbamate, thiourea, and combinations thereof;
- and Z is an anti-neoplastic agent selected from the group consisting of a radionuclide selected from the group consisting of Yttrium-90, Iodine-125, Iodine-131, and Phosphate-32;
- an iodoaryl group bearing an Iodine-131;
- hydroxyurea;
- 3-aminopyridine-2-carboxaldehyde thiosemicarbazone;
- 5-hydroxypyridine-2-carboxaldehyde thiosemicarbazone;
- camptothecin and its analogs;
- carboplat and its analogs;
- DOTA:
- methotrexate and its analogs;
- mitoxantrone, doxorubicin, idarubicin, balrubicin, eprubicin, imatinib, dacarbazine and procarbazine;
- and mitomycin;
- each X is independently selected from the group consisting of O and NH;
- and R1, R3 and R4 are each members independently selected from the group consisting of H, (C1–C12)alkyl and (C1–C12)acyl.
A compound of structure:
- wherein R is SnX3, wherein X is independently selected from the group consisting of a linear or branched C1–C6 alkyl, Br, triflate (OSO2CF3), amino, and a protected amino group.
Dependencies are inferred from the claim text.