Tribonectins
AssigneeRhode Island Hospital
InventorGregory D. Jay
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Abstract
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
Claims13
An isolated tribonectin comprising a boundary-lubricating amount of a polypeptide, said polypeptide comprising the amino acid sequence of SEQ ID NO:1 and at least one O-linked oligosaccharide moiety, wherein the molecular weight of said tribonectin is in the range of 220–280 kDa.
A composition comprising a boundary-lubricating polypeptide encoded by a nucleic acid construct, said construct comprising a human megakaryocyte stimulating factor coding sequence, wherein said megakaryocyte stimulating factor coding sequence consists of exon 1–4 and 6–12 of a human megakaryocyte stimulating factor gene and lacks exon 5 of said megakaryocyte stimulating factor gene.
A composition comprising a boundary-lubricating polypeptide encoded by a nucleic acid construct, said construct comprising a human megakaryocyte stimulating factor coding sequence, wherein said megakaryocyte stimulating factor coding sequence consists of exon 1, 3 and 6–12 of a human megakaryocyte stimulating factor gene and lacks at least one of exons 2, 4 or 5 of said megakaryocyte stimulating factor gene.
A composition comprising a boundary-lubricating polypeptide encoded by a nucleic acid construct, said construct comprising a human megakaryocyte stimulating factor coding sequence, wherein said megakaryocyte stimulating factor coding sequence consists of exon 1 and 6–12 of a human megakaryocyte stimulating factor gene and lacks at least one of exons 2–5 of said megakaryocyte stimulating factor gene.
Dependencies are inferred from the claim text.