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US 7,001,770 B1Granted
Calpain inhibitors and their applications
AssigneeCanji, Inc.
InventorsIsabella A. Atencio, Drake M. LaFace, Muralidhara Ramachandra, Paul W. Shabram
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AssigneeCanji, Inc.
InventorsIsabella A. Atencio, Drake M. LaFace, Muralidhara Ramachandra, Paul W. Shabram
Estimating the term…
The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a calpain inhibitor. the present invention further provides a method of enhancing transciption of a therapeutic transgene from the CMV promoter. The present invention also provides a method of suppress the in vivo CTL response to viral vectors by the use of calpain inhibitors. The present invention further provides a pharmaceutical formulations of p53 and a calpain inhibitor in a pharmaceutically acceptable carrier. The present invention provides a method of ablating neoplastic cells in a mammalian organism in vivo by the co-administration of a calpain inhibitor and p53. The present invention also provides a method of ablating neoplastic cells in a population of normal cells contaminated by said neoplastic cells ex vivo by the administration of a recombinant adenovirus in combination with a calpain inhibitor to said population.
A method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a micro-calpain inhibitor wherein said method is practiced ex vivo, and wherein said method comprises selecting a cell whose infectivity is to be increased, and co-administering said micro-calpain inhibitor and said viral vector to said cell.
A method of infecting a human cell with a virus, comprising:
Dependencies are inferred from the claim text.