Hepatitis B virus vectors for gene therapy
AssigneeWang-Schick Ryu
InventorsWang-Shick Ryu, Jehan Lee, Jong Keun Jeong, Woo Young Cho, Gye Soon Yoon
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Abstract
The present invention relates to novel hepatitis B virus vectors for use in gene therapy which can deliver therapeutic genes to liver cells. The invention also provides methods for the production of novel recombinant hepatitis B viruses. The recombinant viruses produced by this invention can deliver therapeutic genes specifically to liver cells either through in vivo or ex vivo therapy protocols. This vector can be used not only to treat liver diseases but also genetic diseases.
Claims10
A prototype hepatitis B virus vector comprising two novel cis-acting elements essential for hepatitis B virus genome replication, consisting of an α element and a β element, whose nucleotide sequences are described in SEQ ID 1 and 2, respectively.
Dependencies are inferred from the claim text.