Skin friendly active substance patch for transdermal administration of hyperemic active substances
AssigneeBeiersdorf AG
InventorsDetlev Radloff, Matthias Wasner
Life of this patent
Estimating the term…
Abstract
An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and comprising: a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-α-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 μm, and d) from 0.001 to 20% by weight of the hyperemic active substance.
Claims15
An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix adjacent thereto, said adhesive matrix being free from mineral oils and tackifier resins and comprising:
- a) from 25 to 90% by weight of one or more polyisobutylene-based synthetic framework polymers,
- b) from 5 to 40% by weight of one or more amorphous poly-α-olefins,
- c) from 10 to 60% by weight of one or more insoluble hydrophilic fillers having an average particle size of less than 100 μm, and
- d) from 0.001 to 20% by weight of one or more hyperemic active substances.
A process for making an active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising the steps of:
- producing a homogenized melt comprising from 25 to 90% by weight of one or more polyisobutylene-based synthetic framework polymers, from 5 to 40% by weight of one or more amorphous poly-α-olefins, from 10 to 60% by weight of one or more insoluble hydrophilic fillers having an average particle size of less than 100 μm, and from 0.001 to 20% by weight of one or more hyperemic active substances, said melt being free of solvents, mineral oils and tackifier resins;
- and
- applying the melt to a flexible backing layer.
Dependencies are inferred from the claim text.