Methods for treating inflammation with 2F1 antibody
AssigneeImmunex Corporation
InventorsPatricia Parnet, John E. Sims
Life of this patent
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Abstract
2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
Claims5
A method for treating a mammal afflicted with an inflammatory disorder, comprising administering to said mammal a composition comprising an antibody which binds a polypeptide selected from the group consisting of
- a) amino acids −19 to 522 of SEQ ID NO:2;
- b) amino acids 1 to 522 of SEQ ID NO:2;
- c) amino acids −19 to 310 of SEQ ID NO:2;
- d) amino acids 1 to 310 of SEQ ID NO:2;
- and
- e) the polypeptide of any one of a)-d) above, with the exception that amino acid 298 is deleted.
A method for treating a mammal afflicted with an inflammatory bowel disease, comprising administering to said mammal a composition comprising an antibody which binds a polypeptide selected from the group consisting of
- a) aminoacids −9 to 522 of SEQ ID NO:2;
- b) amino acids 1 to 522 of SEQ ID NO:2;
- c) amino acids −19 to 310 of SEQ ID NO:2;
- d) amino acids 1 to 310 of SEQ ID NO:2;
- and
- e) the polypeptide of any one of a)-d) above, with the exception that amino acid 298 is deleted.
Dependencies are inferred from the claim text.