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US 7,001,588 B2Granted
Expanded porphyrin compositions for tumor inhibition
AssigneeCylene Pharmaceuticals, Inc.
InventorLaurence H. Hurley
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Abstract
Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region. Accordingly, these expanded porphyrins are useful to modulate the expression of genes controlled by the formation of c-MYC type G-quadruplexes, such as c-MYC itself.
Claims6
An expanded porphyrin or a conjugate thereof comprising at least five pyrrole rings or pyrrole mimics wherein at least two NH or N moieties contained in said pyrrole rings or pyrrole mimics are replaced by S, Se and/or Te;
- said replacements occurring in non-adjacent pyrrole rings or pyrrole mimics;
- wherein said expanded porphyrin is substituted with at least one R1 moiety which is cationic under physiological conditions;
- and
- wherein said porphyrin may optionally be substituted by one or more non-interfering substituents and one or more carbons contained in a pyrrole ring may be replaced by O or S.
1 more element
Dependencies are inferred from the claim text.