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US 7,001,496 B2Granted
Electropipettor and compensation means for electrophoretic bias
AssigneeCaliper Life Sciences, Inc.
InventorsJ. Wallace Parce, Michael R. Knapp
Life of this patent
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Abstract
A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically connected together by a salt bridge (133), such as a glass frit or gel layer. The salt bridge (133) separates the fluids in channel (140) from an ionic fluid reservoir (135). To impart electroosmotic and electrophoretic forces along the channel (140) between parts A and B, respectively. Additionally, a third electrode (137) is placed in the reservoir (135).
Claims12
A microfluidic device comprising:
- a planar substrate having at least a first microfluidic channel disposed therein, the first microfluidic channel having at least one cross-sectional dimension of less than about 100 microns;
- and
- a pipettor extending from the substrate and having a first capillary channel disposed therein, the first capillary channel having at least one cross-sectional dimension of less than about 100 microns and being fluidly connected at a first end to the first microfluidic channel.
Dependencies are inferred from the claim text.