Method for performing submicroliter crystallization experiments with high experiment to experiment precision
AssigneeThe Regents of the University of California
InventorsBernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Abstract
A method is provided for forming crystallization experiments for a molecule, the method comprising forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments, the crystallization experiments having a volume less than 1 microliter, the volumes of the plurality of crystallization experiments varying among the experiments by less than 25 nL.
Claims82
A method for forming crystallization experiments for a molecule, the method comprising:
- forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments, the crystallization experiments having a volume less than 1 microliter, the volumes of the plurality of crystallization experiments varying among the experiments by less than 25 nL.
A method for performing crystallization experiments for a molecule, the method comprising:
- forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments, the crystallization experiments having a volume less than 1 microliter, the volumes of the plurality of crystallization experiments varying among the experiments by less than 25 nL;
- storing the plurality of crystallization experiments;
- and
- detecting crystal formation in the plurality of crystallization experiments.
Dependencies are inferred from the claim text.