Matrix composition for human grafts/implants
AssigneeRegeneration Technologies, Inc.
InventorsC. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
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Abstract
The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes measured at 25° C. In another aspect, the present invention is directed to a tissue implant comprising a human muscle tissue matrix.
Claims21
An intermediate composition for producing a matrix suitable implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes at 25° C., wherein said shredded allogeneic human muscle tissue is lyophilized and shredded into a coarse fiber prior to said digestion with a biocompatible acid.
A tissue implant suitable for treating an injury or a medical condition in a human comprising a matrix of digested allogeneic human muscle.
A method for making a muscle tissue slurry comprising the steps of:
- i. removing the fat and soluble proteins from allogeneic or xenographic mammalian muscle tissue;
- ii. lyophilizing the muscle tissue from step (i);
- iii. shredding the lyophilized muscle tissue;
- and
- iv. mixing the shredded muscle tissue in an aqueous carrier to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistoke.
A method for making an implantable tissue comprising the steps of:
- i. removing the fat and soluble proteins from allogeneic or xenographic mammalian muscle tissue;
- ii. lyophilizing the muscle tissue from step (i);
- iii. shredding the lyophilized muscle tissue;
- iv. mixing the shredded muscle tissue in an aqueous carrier to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes;
- v. transferring the muscle tissue slurry to an appropriate shaped mold;
- and
- vi. drying the slurry in the mold to form the correspondingly shaped tissue implant.
Dependencies are inferred from the claim text.