Method for treating ischemia
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsEvgenia Mandrusov, Jeffrey Steward, Marshall Sherman
Life of this patent
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Abstract
A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
Claims36
A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration gradient is formed by creating a first lesion in the ischemic region or in the tissue of the region adjacent the ischemic region and creating a second lesion in the ischemic region or in the tissue of the region adjacent the ischemic region, and wherein the lesions have different sizes.
A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration of the angiogenesis stimulating substance is highest at about the center of the ischemic region.
A method of treating an ischemic region of a patient, comprising creating a concentration gradient of an angiogenesis stimulating substance in the ischemic region and/or in tissue of a region adjacent the ischemic region, wherein the concentration of the angiogenesis stimulating substance is lower in the ischemic region than in the tissue of the region adjacent the ischemic region.
A method of treating a region of ischemic tissue in a patient, comprising triggering the release of an angiogenesis stimulating substances to create a concentration variance of the angiogenesis stimulating substances in the region of ischemic tissue and/or in tissue of a region adjacent the region of ischemic tissue, wherein the concentration variance is formed by creating a first lesion in the ischemic region or in the region adjacent the ischemic region and creating a second lesion in the ischemic region or in the region adjacent the ischemic region, and wherein the lesions have different sizes.
A method of treating a region of ischemic tissue in a patient, comprising triggering the release of an angiogenesis stimulating substance to create a concentration variance of the angiogenesis stimulating substance in the region of ischemic tissue and/or in tissue of a region adjacent the region of ischemic tissue, wherein the angiogenesis stimulating substance is released by the tissue of the region adjacent to the region of ischemic tissue.
A method of treating ischemic myocardial tissue of a patient, comprising:
- inserting into the patient a catheter having a tissue stimulating device;
- positioning the tissue stimulating device on or near the ischemic myocardial tissue;
- and
- stimulating the ischemic myocardial tissue and/or myocardial tissue near the ischemic myocardial tissue without piercing or cutting the myocardial tissue to trigger the release of an angiogenic factor.
A method of treating a patient, comprising:
- inserting into the patient a catheter assembly having a tissue stimulating device;
- positioning the tissue stimulating device over or near a ischemic region;
- using the tissue stimulating device to cause the release of an angiogenic substance without piercing or cutting the tissue over which the tissue stimulating device is positioned.
Dependencies are inferred from the claim text.