Inhibitors of receptor activator of NF-κB and uses thereof
AssigneeResearch Development Corporation
InventorsBharat Aggarwal, Bryant G. Darnay, Sujay Singh
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Abstract
The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.
Claims13
A polypeptide that inhibits signaling mediated by TNF receptor-associated factor 6 (TRAF6), wherein said polypeptide comprises a TRAF6 binding domain and a leader signal sequence.
Dependencies are inferred from the claim text.