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US 6,995,363 B2Granted
Reduction of matrix interference for MALDI mass spectrometry analysis
AssigneesApplera Corporation, MDS Inc.
InventorsMichael P. Donegan, Andrew J. Tomlinson, Perumanath H. Nair, Peter Juhasz
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Abstract
A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (<1,000 daltons) of a MALDI-MS spectrum.
Claims12
A sample plate for MALDI analysis comprising:
- an electrically conductive substrate having a first surface, at least a portion of the first surface coated with a composite coating that comprises a hydrophobic coating and a coating of a thin film mixture of a matrix and an intercalating polymer.
The process for making a sample plate for MALDI MS or MS-MS analysis comprising:
- forming a hydrophobic coating on a first surface of an electrically conductive substrate;
- and
- forming a second coating on the first surface and the hydrophobic coating with a mixture in solution containing a matrix and an intercalating polymer to form a composite coating on the substrate.
Dependencies are inferred from the claim text.