Nitrogen containing heterocyclic compounds and medicines containing the same

A compound represented by the following formula:

• wherein X2 represents methylene, 1,2-ethylene or 1,1-ethylene;
• wherein -X3-X4- is methylene, oxygen, a single bond or a group represented by the formula;
• wherein X40 represents (1) methylene having between 0 and 2 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, and cyano, (2) oxygen, (3) -CO- , (4) -S-, (5) -S(O)- or (6) -S(O)2-;
• X41 represents methylene having between 0 and 2 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, and cyano;
• R34 represents C1-6 alkyl;
• R41 represents (1) phenyl having between 0 and 3 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, and cyano,
• (2) phenyl-C1-6 alkyl having between 0 and 3 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, and cyano or (3) C1-6 alkyl having between 0 and 3 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkoxy, and cyano;
• and
• R42 represents (1) C1-6 alkyl having between 0 and 3 substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkoxy, and cyano or (2) hydrogen;
• wherein A2 is phenyl having between 0 and 3 substituents selected from Substituent Group A below, 1-naphthyl having between 0 and 3 substituents selected from Substituent Group A below, 2-naphthyl having between 0 and 3 substituents selected from Substituent Group A below, an aromatic ring having 5 to 10 atoms in the ring and containing one or more hetero atoms among the atoms of the ring and having between 0 and 3 substituents selected from Substituent Group A below, or a 9- to 11-membered benzene fused ring group having between 0 and 3 substituents selected from Substituent Group A below;
• wherein Substituent Group A is the group consisting of C1-6 alkyl having between 0 and 3 substituents selected from Substituent Group B below, C1-6 alkoxy having between 0 and 3 substituents selected from Substituent Group B below, halogen, C3-8 cycloalkyl, C2-7 alkoxycarbonyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, cyano, nitro, phenyl, pyridyl, ethylenedioxy, methylenedioxy, a group represented by the formula:
• wherein t1 and t2 each independently represents zero or an integer from 1 to 3, and R80 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl,
• and a group represented by the formula:
• wherein R73 and R74 each independently represents hydrogen, C1-6 alkyl, C2-7 acyl, C1-6 alkylsulfonyl, —CO—NR75R76 or —CS—NR75R76, and R75 and R76 each independently represents hydrogen or C1-6 alkyl;
• wherein Substituent Group B is the group consisting of halogen, C1-6 alkoxy, cyano, hydroxyl, and C3-8 cycloalkyl;
• wherein A1 represents a group represented by the formula:
• wherein R21 represents hydrogen or C1-6 alkyl, and R61a and R62a each independently represents hydrogen, halogen, C1-6 alkoxy, C1-6 alkyl or cayno;
• and
• wherein R51, R53, R54, R55 and R57 each independently represents (1) hydrogen, (2) halogen, (3) cyano, (4) hydroxyl, (5) C2-7 alkoxycarbonyl, (6) C1-6 alkyl having between 0 to 4 substituents selected from the group consisting of hydroxyl, C1-6 alkoxy, and halogen, (7) C1-6 alkoxy having between 0 and 4 substituents selected from the group consisting of hydroxyl, C1-6 alkoxy, and halogen, (8) 2-methylphenyloxymethyl or (9) 2-fluorophenyloxymethyl, a salt thereof or a hydrate of the foregoing.