Pharmaceutical and cosmetic carrier and composition for topical application
AssigneeFoamix Ltd.
InventorsMeir Eini, Dov Tamarkin
Life of this patent
Estimating the term…
Abstract
A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1–25 percent of a solidifying agent and 75–99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
Claims29
A method of treating a disease or disorder of a skin or a mucosal membrane comprising:
- topically administering to the skin or the mucosal membrane a pharmaceutical composition containing, by weight, 1–25 percent of a solidifying agent, wherein the solidifying agent consists essentially of at least one long chain fatty alcohol having at least 15 carbons atoms in its carbon backbone and at least one fatty acid, having at least 18 carbon atoms in its carbon backbone, and 75–99 percent of a hydrophobic solvent, wherein at least one of the solidifying agent and the hydrophobic agent has a therapeutic or cosmetic beneficial effect, and wherein the solidifying agent and the hydrophobic solvent are selected such that under ambient conditions, the composition is semi-solid a rest and liquefies upon application of shear forces thereto,
- wherein the disease or disorder is selected from the group consisting of psoriasis, acne, seborrhea, seborrheic dermatitis, alopecia and excessive hair growth, ichthyosis, wounds, burns, cuts, ulcers, psoriasis, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis and exfoliative dermatitis.
A method of treating a disease or disorder of a skin or a mucosal membrane comprising the step of topically administrating thereto a pharmaceutical composition containing:
- (a) a pharmaceutical or cosmetic carrier containing, by weight, 1–25 percent of a solidifying agent, wherein the solidifying agent consists essentially of at least one long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and at least one fatty acid having at least 18 carbon atoms in its carbon backbone, and 75–99 percent of a hydrophobic solvent;
- and
- (b) a therapeutically or cosmetically effective amount of a biologically active substance,
- wherein the solidifying agent and the hydrophobic solvent are selected such that under ambient conditions, the carrier is semi-solid at rest and liquefies upon application of shear forces thereto, and
- wherein the biologically active substance is effective in the treatment of a disease or disorder selected from the group consisting of psoriasis, acne, seborrhea, seborrheic dermatitis, alopecia and excessive hair growth, ichthyosis, wounds, burns, cuts, ulcers, psoriasis, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis and exfoliative dermatitis.
A method of treating dermatosis of a skin or a mucosal membrane comprising the step of topically administering to the skin or the mucosal membrane a pharmaceutical or cosmetic composition containing,
- (a) a carrier comprising, by weight, 1–12 percent of a solidifying agent consisting essentially of long chain fatty alcohols having 18–22 carbons atoms in its carbon backbone and long chain fatty acids having 18–22 carbon atoms in its carbon backbone and 75–99 percent of a triglyeride hydrophobic solvent;
- and
- (b) a therapeutic or cosmetically effective amount of a biologically active substance that treats a symptom of dermatosis.
Dependencies are inferred from the claim text.