Parallel semicontinuous or continuous reactors

A parallel, semi-continuous or continuous, pressure reactor comprising

• four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels having a volume of not more than about 1 liter, and being pressurizable to a pressure of not less than about 50 psig,
• four or more shaft-driven impellers corresponding to the four or more reaction vessels for stirring the reaction mixtures, and
• at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, such that one or more liquid reagents can be selectively fed from the one or more source vessels to each of the four or more reaction vessels during a reaction under reaction conditions.

A parallel, semi-continuous or continuous, pressure reactor comprising

• four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels being pressurizable to a pressure of not less than about 50 psig,
• at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, such that one or more liquid reagents can be selectively fed from the one or more source vessels to each of the four or more reaction vessels during a reaction under reaction conditions,
• at least one feed-pressurization station pressurizable to a pressure of not less than about 50 psig, at least a portion of each of the at least four liquid feed lines being in selectable fluid communication with the at least one feed-pressurization station, such that said portion of each of the at least four liquid feed lines can be selectively pressurized prior to feeding the one or more liquid reagents to the four or more reaction vessels.

A parallel, semi-continuous or continuous reactor comprising four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels is hermetically sealable and has volume of not more than about 1 liter, at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, four or more modular feed-line subassemblies releasably received in receiving ports in the reaction vessels or in a reactor block that defines or contains the reaction vessels, each of the four or more feed-line subassemblies supporting two or more of the at least four liquid feed lines feeding a respective reaction vessel.

A parallel, semi-continuous or continuous reactor comprising four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels is hermetically sealable and has a volume of not more than about 1 liter, at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, each of the at least four liquid feed lines comprising at least a first section and a second section in fluid communication with each other, the second section being releasable with respect to the first section and having a distal end positioned within a respective one of the reaction vessels.

A parallel, semi-continuous or continuous reactor comprising four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels is hermetically sealable and has a volume of not more than about 1 liter, at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, each of the at least four liquid feed lines having a distal end positioned within the reaction vessel, the distal end of one or more of the liquid feed lines being positioned lower in the reaction vessel relative to the distal end of one or more other of the liquid feed lines.

A parallel, semi-continuous or continuous reactor comprising four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels is hermetically sealable and has a volume of not more than about 1 liter, at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, one or more of the at least four liquid feed lines having an inside diameter or cross-sectional flow area that differs from the inside diameter or cross-sectional flow area for another of the at least four liquid feed lines.

A parallel, semi-continuous or continuous, pressure reactor comprising

• a reactor block comprising four or more semi-continuous or continuous reaction vessels for containing liquid reaction mixtures, each of the four or more reaction vessels being pressurizable to a pressure of not less than about 50 psig,
• four or more shaft-driven impellers corresponding to the four or more reaction vessels for stirring the reaction mixtures, and
• at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, such that one or more liquid reagents can be selectively fed from the one or more source vessels to each of the four or more reaction vessels during a reaction under reaction conditions, wherein each of the least four liquid feed lines in fluid communication with each of the four or more reaction vessels comprises at least a first section and a second section in fluid communication with each other, the second section being releasable with respect to the first section and having a distal end positioned within the reaction vessel, and wherein the first section comprises a polymer capillary and the second section comprises a stainless steel capillary.