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US 6,992,065 B2Granted
Sustained release formulations
AssigneesGenentech, Inc., Durect Corporation
InventorFranklin Okumu
Life of this patent
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Abstract
A composition for sustained release comprises a carrier material containing a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not crytallize neat under ambient physiological conditions, a multivalent metal cation, and growth hormone.
Claims49
A composition for sustained release, comprising:
- a carrier material comprising a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient physiological conditions;
- growth hormone;
- and
- a multivalent metal cation;
- wherein the composition releases at most 4% of the growth hormone in vitro within the first 24 hours as determined by Release Rate Determination.
2 more elements
A composition for sustained release, comprising:
- sucrose acetate isobutyrate;
- a solvent;
- zinc;
- and
- growth hormone;
- wherein the composition releases at most 4% of the growth hormone in vitro within the first 24 hours as determined by Release Rate Determination.
3 more elements
A method of making a sustained release composition, comprising:
- mixing a complex and a liquid carrier to form said sustained release composition;
- wherein said liquid carrier comprises sucrose acetate isobutyrate;
- and
- wherein said complex comprises growth hormone and Zn2+;
- wherein said sustained release composition releases at most 4% of the growth hormone in vitro within the first 24 hours as determined by Release Rate Determination.
2 more elements
Dependencies are inferred from the claim text.