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US 6,992,061 B2Granted
Purification method
AssigneeNational Blood Authority
InventorsJohn Edward More, Jacqueline Rott, David Roger Lewin
Life of this patent
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Abstract
The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprotein which includes this depyrogenation step, and to the depyrogenated product and its clinical uses.
Claims8
An isolated and purified alpha-1-acid glycoprotein (AAG) having a lipopolysaccharide (LPS) concentration of less than or equal to 0.1 Eu/mg AAG.
Dependencies are inferred from the claim text.