Hepatitis A vaccines
AssigneeSmithKline Beecham Biologicals s.a.
InventorErik D′Hondt
Life of this patent
Estimating the term…
Abstract
A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
Claims5
A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination, the process comprising:
- a) a culturing Hepatitis A virus and harvesting a hepatitis A preparation;
- b) treating said hepatitis A preparation with a protease, thereafter;
- c) separating intact virus from protease-digested protein;
- and
- d) inactivating said virus.
Dependencies are inferred from the claim text.