Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
AssigneeKeraplast Technologies, Ltd.
InventorMark E. Van Dyke
Life of this patent
Estimating the term…
Abstract
Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and novel heterogeneous crosslinked networks. Preferred heterogeneous crosslinking agents are silicone-based.
Claims26
A method for making a keratin network crosslinked by a multi-functional crosslinking agent comprising silicone, said method comprising exposing a plurality of α-keratin molecules comprising reactive pendant groups to said crosslinking agent under conditions effective to form covalent interprotein crosslinks between first reactive functionalities on said crosslinking agent and first reactive pendant groups on a first group of said α-keratin molecules, said conditions also being effective to form covalent interprotein crosslinks between second reactive functionalities on said crosslinking agent and second reactive pendant groups on a second group of α-keratin molecules, wherein said crosslinking agent has the following general structure:
- wherein n is from about 1 to about 50;
- and,
- at least two of R1, R2, R3, and R4 comprise at least one reactive functionality;
- wherein R1, R2, R3, and R4 are selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with one or more reactive functionalities, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, or combinations thereof.
A network consisting essentially of keratin molecules comprising interkeratin crosslinks comprising first covalent bonds between first reactive functionalities on a plurality of molecules of a crosslinking agent comprising silicone and first reactive pendant groups on a plurality of first keratin molecules and second covalent bonds between second reactive functionalities on a plurality of molecules of said crosslinking agent and second reactive pendant groups on a plurality of second keratin molecules, wherein said crosslinking agent has the following general structure:
- wherein n is from about 1 to about 50;
- and, A and B are the remainder of first and second protein molecules;
- at least two of R1, R2, R3, and R4 comprise at least one reactive functionality;
- wherein R1, R2, R3, and R4 are selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, or combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1 and R2 are a remainder of a first keratin protein molecule;
- R3 and R4 is a remainder of a second protein molecule;
- and, R5, R6, R7, and R8 are reacted groups selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1, R2 and R3 are a remainder of a first keratin protein molecule;
- R4, R5, and R6 are a remainder of a second keratin protein molecule;
- and, R7, R8, R9 and R10 are selected from the group consisting of cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substituent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1 and R2 are a remainder of a first keratin protein molecule;
- R3 and R4 is a remainder of a second keratin protein molecule;
- and, R5, R6, R7, and R8 are reacted groups selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1 and R2 are a remainder of a first keratin protein molecule;
- R3 and R4 are a remainder of a second keratin protein molecule;
- and, R5, R6, R7, and R8 are reacted groups selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1 and R2 are a remainder of a first keratin protein molecule;
- R3 and R4 is a remainder of a second keratin protein molecule;
- and, R5, R6, R7, and R8 are reacted groups selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
A heterogeneous crosslinked network comprising the following crosslinks:
- wherein R1 and R2 are a remainder of a first keratin protein molecule;
- R3 and R4 is a remainder of a second keratin protein molecule;
- and, R5, R6, R7, and R8 are reacted groups selected from the group consisting of hydrogen;
- cyclic, linear, and branched alkyl and heteroalkyl groups having from about 1 to about 6 carbon atoms, said groups comprising both unsubstituted groups and groups substituted with at least one reactive functionality, wherein said heteroalkyl groups comprise acetoxy groups, silane groups optionally comprising one or more alkyl substitutent having a total of from about 1 to about 6 carbon atoms, and combinations thereof.
Dependencies are inferred from the claim text.