Human CTLA-4 antibodies
AssigneeMedarex, Inc.
InventorsAlan J. Korman, Edward L. Halk, Nils Lonberg, Yashwant M. Deo, Tibor P. Keler
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Abstract
The present invention provides human sequence antibodies against CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
Claims14
An antibody comprising:
- (a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:19;
- and
- (b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:9,
- wherein the antibody is capable of binding human CTLA-4.
An antibody comprising:
- (a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:17;
- and
- (b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:7,
- wherein the antibody is capable of binding human CTLA4.
An antibody comprising:
- (a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:23;
- and
- (b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:13,
- wherein the antibody is capable of binding human CTLA4.
An antibody capable of binding human CTLA4, which antibody comprises:
- (a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:27, 32 and 37;
- and
- (b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:24, 29 and 35.
An antibody capable of binding human CTLA4, which antibody comprises:
- (a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:27, 33 and 37;
- and
- (b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:25, 30 and 35.
An antibody capable of binding human CTLA4, which antibody comprises:
- (a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:28, 34 and 38;
- and
- (b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:26, 31 and 36.
An antibody capable of binding human CTLA4, which antibody comprises:
- (a) a heavy chain variable region of a human VH 3-30.3 gene;
- and
- (b) a light chain variable region of a human VK A-27 gene.
An antibody capable of binding human CTLA4, which antibody comprises:
- (a) a heavy chain variable region of a human VH 3-33 gene;
- and
- (b) a light chain variable region of a human VK L-15 gene.
Dependencies are inferred from the claim text.