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US 6,984,656 B2Granted
Core modified porphyrins
AssigneeThe Research Foundation of State University of New York
InventorsMichael R. Detty, Sandra O. Gollnick, Sherry Davies, Allan Oseroff, Masako Abe, David Hilmey
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Abstract
The present invention is directed to novel photosensitive compounds that can be replicated with great certainty and provide applications for photodynamic therapy.
Claims15
A photosensitive compound of the formula:
- wherein;
- A and A′ are
- wherein X is H, F or NME2;
- E is selected from the group consisting of S, Se, and Te;
- E′ is selected from the group consisting of S, Se, and Te;
- A″ and A′″ are
- wherein Y is SO3 or OCH2CO2.
4 more elements
A photosensitive compound of the formula:
- wherein Ar is selected from the group consisting of Ph, 4-FC6H4, 4-MeC6H4, and 2-thienyl;
- and Ar′ is selected from the group consisting of Ph, 4-FC6H4, 4-MeC6H4, 4-EtC6H4, and 4-n-BuC6H4.
A method of providing photodynamic therapy to a patient in need thereof, the method comprising:
- administering to the patient in a pharmaceutically acceptable delivery vehicle a photodynamic therapy therapeutic dose of a compound with the following structure:
- wherein Ar is selected from the group consisting of Ph, 4-FC6H4, 4-MeC6H4, and 2-thienyl;
- and Ar′ is selected from the group consisting of Ph, 4-FC6H4, 4-MeC6H4, 4-EtC6H4, and 4-n-BuC6H4;
- waiting a sufficient time to allow the administered compound to be taken up and retained in at least one target tissue;
- and
- irradiating a region of the patient containing the target tissue.
3 more elements
Dependencies are inferred from the claim text.